NDLI: Multiple stages in radiation carcinogenesis of rat skin.

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Multiple stages in radiation carcinogenesis of rat skin.

Content Provider	Semantic Scholar
Author	Burns, F. J. Albert, Roy E. Garte, Seymour J.
Copyright Year	1989
Abstract	Epithelial cell cancers are induced in rat skin by ionizing radiation in a manner that is consistent with the dual action (i.e., two alterations) hypothesis of radiation effects on DNA. This hypothesis states simply that two initial alterations, presumably in the DNA, are necessary to start a normal cell on the pathway to cancer. The initial radiation-induced alteration in the DNA is repairable as indicated by the reduction in tumor incidence with increasing time between dose fractions; the repair halftime is estimated to be 3.0 +/- 1.0 hr. Theoretical predictions of a specific dependence of tumor incidence on linear energy transfer (LET) have been verified experimentally for two specific LET values. However, the theoretical formulation provides no guidance regarding the observed reduction in the carcinogenic action of radiation with age at the time of exposure. Analysis of the tumor DNA for oncogene activation indicated k-ras and c-myc oncogenes were activated in highly anaplastic rat skin cancers, whereas only one of these oncogenes, usually c-myc, was activated in comparatively benign basal cell carcinomas and in squamous cell carcinomas.
Starting Page	67
Ending Page	72
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	2667987
Volume Number	81
Journal	Environmental health perspectives
Alternate Webpage(s)	http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=72DE53BA79D980112DA7FE4BC4040320?doi=10.1.1.277.2794&rep=rep1&type=pdf
Language	English
Access Restriction	Open
Subject Keyword	Basal cell carcinoma Carcinogenesis Carcinogenesis, Radiation Dual Energy Transfer Ionizing radiation Leukemia, B-Cell Lupus erythematosus tumidus MYC gene MYC wt Allele Malignant Neoplasms Oncogene Activation Process Oncogenes Skin Neoplasms Squamous Epithelial Cells Squamous cell carcinoma
Content Type	Text
Resource Type	Article

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