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Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition† †Electronic supplementary information (ESI) available: Full experimental details and copies of 1H, 13C, 31P NMR spectra for all compounds. See DOI: 10.1039/c6ob00007j Click here for additional data file.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Palframan, Matthew J. Alharthy, Rima D. Powalowska, Paulina Klaudyna Hayes, Christopher J. |
| Copyright Year | 2016 |
| Abstract | Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification. |
| Starting Page | 3112 |
| Ending Page | 3119 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C6OB00007J |
| PubMed reference number | 26905296 |
| Volume Number | 14 |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/articlepdf/2016/ob/c6ob00007j |
| Alternate Webpage(s) | http://eprints.nottingham.ac.uk/35070/7/c6ob00007j.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C6OB00007J |
| Journal | Organic & Biomolecular Chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |