NDLI: Cytotoxic Effect of Turkish Propolis on Liver , Colon , Breast , Cervix and Prostate Cancer Cell Lines

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Cytotoxic Effect of Turkish Propolis on Liver , Colon , Breast , Cervix and Prostate Cancer Cell Lines

Content Provider	Semantic Scholar
Author	Turan, Ibrahim Sema Kilinç, Kağan Menteşe, Ahmet Aliyazicioglu, Yuksel Deḡer, Orhan
Copyright Year	2015
Abstract	Purpose: To investigate the total polyphenolic and flavonoid contents, antioxidant power and cytotoxic activity of ethanol extracts of Turkish propolis (EEP). Methods: The total polyphenolic and flavonoid contents of EEP were determined by spectrometric methods. Antioxidant power and cytotoxic activity of EEP were evaluated using ferric reducing antioxidant power (FRAP) and MTT assays, respectively. Results: The total polyphenolic and flavonoid contents, and FRAP value of EEP were 124.6 ± 1.5 mg gallic acid/g sample dry weight , 42.0 ± 0.8 mg quercetin/g sample dry weight and 311.0 ± 2.5 mg trolox/g sample dry weight, respectively. EEP exhibited powerful cytotoxic effects against the five human cancer cell lines. The highest cytotoxic activity of Turkish EEP was demonstrated on PC-3 cell line (IC50 = 20.7±3.4 μg/mL). Conclusion: The results demonstrate that EEP is a good source of antioxidant and a natural antitumor agent capable of reducing cancer cell proliferation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bioline.org.br/pdf?pr15101
Language	English
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Cell Proliferation Colon classification Cultured Cell Line Ethanol Flavonoids Fraps Gallic acid Inhibitory Concentration 50 Phenol formaldehyde resin Probability Propolis Prostate carcinoma Prostatic Neoplasms Quercetin Turkish Informatics Olympiad UK Educational Evidence Portal USB hub cancer cell contents - HtmlLinkType ferric oxide monooxyethylene trimethylolpropane tristearate
Content Type	Text
Resource Type	Article

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