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HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis.
Content Provider | Semantic Scholar |
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Author | Najafi, Shamsolmoulouk Mohammadzadeh, Mahsa Bidoki, Alireza Zare Zare Meighani, Ghasem Aslani, Saeed Mahmoudi, Mahdi Rezaei, Nima Attaran |
Copyright Year | 2016 |
Abstract | Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated. Our data indicated that DRB1*13:17, DRB1*15:01, and DRB5*01 were significantly more frequent in RAS patients in comparison to controls. However, DRB3:01allele frequency was higher in the controls compared to the patients. The significantly frequent allele in the patients compared with the healthy subjects was HLA-DQB1*03:02. However, both HLA-DQB1*02:01 and HLA-DQB1*03:01 alleles were most frequent in the healthy individuals rather than the patients. The DRB*04/DQB1*03:01 and DRB*01:01/DQB1*02:01 haplotypes were significantly distributed in healthy subjects compared with patients. However, DRB*07:01/DQB1*03:02 haplotype was found to be significantly frequent in patients than controls. In respect of HLA genes, factors are involved in the incidence of RAS; various HLA-DRB and HLA-DQB1 alleles and the related haplotypes are suggested to be the three main RAS susceptibility factors in our population study. |
Starting Page | 289 |
Ending Page | 295 |
Page Count | 7 |
File Format | PDF HTM / HTML |
Alternate Webpage(s) | http://ijaai.tums.ac.ir/index.php/ijaai/article/download/710/643 |
PubMed reference number | 27921409v1 |
Volume Number | 15 |
Issue Number | 4 |
Journal | Iranian journal of allergy, asthma, and immunology |
Language | English |
Access Restriction | Open |
Subject Keyword | Alleles Aphthous Stomatitis Chronic disease Dental caries Dichlororibofuranosylbenzimidazole Gene Frequency HLA Antigens HLA-DQ Antigens HLA-DQB1 wt Allele HLA-DR Antigens Haplotypes Histocompatibility Antigens Class II Leukocytes Oral cavity Patients Recurrent aphthous ulcer human histocompatibility complex derived antigens-DQ alpha:Type:Point in time:Whole blood:Nominal recurrent childhood brain stem glioma |
Content Type | Text |
Resource Type | Article |