NDLI: HLA-DRB 1 , DQA 1 and DQB 1 Alleles and Haplotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombinant Hepatitis B Vaccine

Please wait, while we are loading the content...

HLA-DRB 1 , DQA 1 and DQB 1 Alleles and Haplotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombinant Hepatitis B Vaccine

Content Provider	Semantic Scholar
Author	Amirzargar, Ali Akbar Mohseni, Nilufar Shokrgozar, Mohammad Ali Arjang, Zohreh Ahmadi, Nahid Behzadi, Manijeh Yousefi Amanzadeh, Amir Shokri, Fazel
Copyright Year	2008
Abstract	Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte antigen (HLA) class-II alleles or haplotypes. Objectives: The present study was undertaken to determine the frequency of HLA class-II alleles in Iranian healthy adult responders and non-responders to HB vaccine. Methods: Twelve non-responders (antiHBs antibody<10 IU/L) and 46 responders (anti-HBs antibody>100 IU/L) were tissue typed for HLA class-II. HLA-DRB1, DQB1 and DQA1 alleles were determined using polymerase chain reaction based on sequence specific primers (PCR-SSP) technique. Accessibility to excess amount of genomic DNA was possible using Epstein-Barr virus (EBV)-transformed B-cells established from all vaccinees. Results: Our results demonstrated increased frequencies of HLADRB107, DRB103, DRB104, DQB10201, DQA10201 alleles and HLADRB107/DQB10201/DQA10201 and DRB104/DQB10302/DQA103011 haplotypes in the non-responder group. Comparison between responders and non-responders revealed only a significant difference for DQB10201 allele (p<0.05). Conclusion: These findings confirm the association of certain HLA alleles and haplotypes with the lack of antibody response to HB vaccine in an Iranian population.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.sid.ir/en/VEWSSID/J_pdf/100820080202.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in