Loading...
Please wait, while we are loading the content...
Similar Documents
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
Content Provider | Semantic Scholar |
---|---|
Author | Sollid, Ludvig M. Markussen, G. Ek, Johan Gjerde, Hallvard Vartdal, Frode Thorsby, Erik |
Copyright Year | 1989 |
Abstract | Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer. |
Starting Page | 345 |
Ending Page | 350 |
Page Count | 6 |
File Format | PDF HTM / HTML |
PubMed reference number | 2909659 |
Volume Number | 169 |
Journal | The Journal of experimental medicine |
Alternate Webpage(s) | http://jem.rupress.org/content/jem/169/1/345.full.pdf |
Language | English |
Access Restriction | Open |
Subject Keyword | Celiac Disease DNA Probes, HLA Haplotypes Histocompatibility Antigens Class II Patients human histocompatibility complex derived antigens-DQ alpha:Type:Point in time:Whole blood:Nominal |
Content Type | Text |
Resource Type | Article |