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HLA profile in patients with AIDS and tuberculosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Figueiredo, José Fernando De Castro Rodrigues, Maria De Lourdes Veronese Deghaide, Neifi Hassam Saloum Donadi, Eduardo Antônio |
| Copyright Year | 2008 |
| Abstract | Studies carried out in various populations have reported an association between some HLA specificities and susceptibility to tuberculosis. We investigated the class I and class II HLA profile in Brazilian patients of various ethnic backgrounds who had AIDS and tuberculosis. Twenty-two adult patients with AIDS and tuberculosis (Group I), 103 patients with AIDS without tuberculosis (Group II) and 423 healthy individuals not infected with HIV (Group III) were evaluated. Diagnosis of HIV infection was made by ELISA, confirmed by a gelatin particle agglutination test. Diagnosis of tuberculosis was made based on clinical/radiological presentation and direct bacilloscopy or clinical specimen cultures. Class I antigens were typed by microlymphotoxicity. Class II alleles were characterized by the polymerase chain reaction (PCR). Differences in frequency of HLA specificities between groups were found in the following antigens/alleles: Group I x Group II: HLA-A31 - p=0.026; HLA-B41 - p= 0.037; HLA-DRB1*10 - p=0.037; HLA-DQB1*5 - p=0.009. Group I x Group III (control): HLA-A31 - p = 0.000008; odds ratio (OR)=31.75; HLA-B41 - p=0.003; HLA-DQB1*5 - p=0.02. HLA-A31 and HLA-B41 antigens and the HLA-DRB1*10 and HLA-DQB1*05 alleles were over-represented in patients with AIDS and tuberculosis (Group I), suggesting that these HLA molecules are associated with susceptibility to tuberculosis in Brazilian patients with AIDS. |
| Starting Page | 11 |
| Ending Page | 11 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/bjid/v12n4/a04v12n4.pdf |
| Alternate Webpage(s) | http://www.producao.usp.br/bitstream/handle/BDPI/7467/art_DONADI_HLA_profile_in_patients_with_AIDS_and_2008.pdf;jsessionid=7F2D094F4C137D4B7B632509E6AF2094?sequence=1 |
| Alternate Webpage(s) | http://www.producao.usp.br/bitstream/handle/BDPI/7467/art_DONADI_HLA_profile_in_patients_with_AIDS_and_2008.pdf;jsessionid=24193797320959140F3D4E4FB0ACA61F?sequence=1 |
| Alternate Webpage(s) | http://www.producao.usp.br/bitstream/handle/BDPI/7467/art_DONADI_HLA_profile_in_patients_with_AIDS_and_2008.pdf;jsessionid=DA8276432E41DA7C741FE72A1969280B?sequence=1 |
| PubMed reference number | 19030725v1 |
| Volume Number | 12 |
| Issue Number | 4 |
| Journal | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acquired Immunodeficiency Syndrome Agglutination Tests Alleles Enzyme-Linked Immunosorbent Assay HIV Antigens HIV Infections HLA Antigens HLA tissue typing antigens HLA-DQ Antigens HLA-DQB1 wt Allele HLA-DRB1 antigen Histocompatibility Antigens Class II Odds Ratio Patients Polymerase Chain Reaction Tuberculosis |
| Content Type | Text |
| Resource Type | Article |
