NDLI: Ypt1 recruits the Atg1 kinase to the preautophagosomal structure.

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Ypt1 recruits the Atg1 kinase to the preautophagosomal structure.

Content Provider	Semantic Scholar
Author	Wang, Juan Menon, Shekar Yamasaki, Akinori Chou, Hui-Ting Walz, Thomas Jiang, Yu Ferro-Novick, Susan
Copyright Year	2013
Abstract	When macroautophagy, a catabolic process that rids the cells of unwanted proteins, is initiated, 30-60 nm Atg9 vesicles move from the Golgi to the preautophagosomal structure (PAS) to initiate autophagosome formation. The Rab GTPase Ypt1 and its mammalian homolog Rab1 regulate macroautophagy and two other trafficking events: endoplasmic reticulum-Golgi and intra-Golgi traffic. How a Rab, which localizes to three distinct cellular locations, achieves specificity is unknown. Here we show that transport protein particle III (TRAPPIII), a conserved autophagy-specific guanine nucleotide exchange factor for Ypt1/Rab1, is recruited to the PAS by Atg17. We also show that activated Ypt1 recruits the putative membrane curvature sensor Atg1 to the PAS, bringing it into proximity to its binding partner Atg17. Since Atg17 resides at the PAS, these events ensure that Atg1 will specifically localize to the PAS and not to the other compartments where Ypt1 resides. We propose that Ypt1 regulates Atg9 vesicle tethering by modulating the delivery of Atg1 to the PAS. These events appear to be conserved in higher cells.
Starting Page	122
Ending Page	130
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/110/24/9800.full.pdf
PubMed reference number	23716696v1
Alternate Webpage(s)	https://doi.org/10.1073/pnas.1302337110
DOI	10.1073/pnas.1302337110
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume Number	110
Issue Number	24
Language	English
Access Restriction	Open
Subject Keyword	Anatomical compartments Autophagy Carrier Proteins Endoplasmic Reticulum Golgi Apparatus Guanine Nucleotide Exchange Factors Guanine Nucleotides Mammals Tissue membrane ULK1 protein, human Vesicle (morphologic abnormality) autophagosome assembly pre-autophagosomal structure transport protein particle location
Content Type	Text
Resource Type	Article

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