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Cargo Capture and Bulk Flow in the Early Secretory Pathway.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Barlowe, Charles K. Helenius, Ari |
| Copyright Year | 2016 |
| Abstract | Transport of newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi complex is highly selective. As a general rule, such transport is limited to soluble and membrane-associated secretory proteins that have reached properly folded and assembled conformations. To secure the efficiency, fidelity, and control of this crucial transport step, cells use a combination of mechanisms. The mechanisms are based on selective retention of proteins in the ER to prevent uptake into transport vesicles, on selective capture of proteins in COPII carrier vesicles, on inclusion of proteins in these vesicles by default as part of fluid and membrane bulk flow, and on selective retrieval of proteins from post-ER compartments by retrograde vesicle transport. |
| Starting Page | 197 |
| Ending Page | 222 |
| Page Count | 26 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.mcb5068.wustl.edu/MCB/Lecturers/Hanson/2016%20Readings/Barlowe_Helenius_2016.pdf |
| PubMed reference number | 27298089v1 |
| Volume Number | 32 |
| Journal | Annual review of cell and developmental biology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomical compartments Cell secretion Endoplasmic Reticulum Golgi Apparatus Secretory Pathway Tissue membrane Transport Vesicles Vesicle (morphologic abnormality) vesicle-mediated transport |
| Content Type | Text |
| Resource Type | Article |
