Loading...
Please wait, while we are loading the content...
Similar Documents
Rabs and their effectors: achieving specificity in membrane traffic.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Grosshans, Bianka L. Ortiz, Darinel Novick, Peter J. |
| Copyright Year | 2006 |
| Abstract | Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the guanine nucleotide-dependent switch mechanism common to the superfamily to regulate each of the four major steps in membrane traffic: vesicle budding, vesicle delivery, vesicle tethering, and fusion of the vesicle membrane with that of the target compartment. These different tasks are carried out by a diverse collection of effector molecules that bind to specific Rabs in their GTP-bound state. Recent advances have not only greatly extended the number of known Rab effectors, but have also begun to define the mechanisms underlying their distinct functions. By binding to the guanine nucleotide exchange proteins that activate the Rabs certain effectors act to establish positive feedback loops that help to define and maintain tightly localized domains of activated Rab proteins, which then serve to recruit other effector molecules. Additionally, Rab cascades and Rab conversions appear to confer directionality to membrane traffic and couple each stage of traffic with the next along the pathway. |
| Starting Page | 3 |
| Ending Page | 12 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/103/32/11821.full.pdf |
| PubMed reference number | 16882731v1 |
| Volume Number | 103 |
| Issue Number | 32 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action Anatomical compartments Guanine Nucleotides Guanosine Triphosphate Largest Membrane Protein Traffic Vesicle (morphologic abnormality) vesicle membrane |
| Content Type | Text |
| Resource Type | Article |
