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Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Uhlig, Holm H. Mckenzie, Brent Hue, Sophie Thompson, Claire Joyce-Shaikh, Barbara Štěpánková, Renata Robinson, Nicolas Buonocore, Sofia Tlaskalova-Hogenova, Helena Cua, Daniel J. Powrie, Fiona |
| Copyright Year | 2006 |
| Abstract | The CD40-CD154 pathway is important in the pathogenesis of inflammatory bowel disease. Here we show that injection of an agonistic CD40 mAb to T and B cell-deficient mice was sufficient to induce a pathogenic systemic and intestinal innate inflammatory response that was functionally dependent on tumor necrosis factor-alpha and interferon-gamma as well as interleukin-12 p40 and interleukin-23 p40 secretion. CD40-induced colitis, but not wasting disease or serum proinflammatory cytokine production, depended on interleukin-23 p19 secretion, whereas interleukin-12 p35 secretion controlled wasting disease and serum cytokine production but not mucosal immunopathology. Intestinal inflammation was associated with IL-23 (p19) mRNA-producing intestinal dendritic cells and IL-17A mRNA within the intestine. Our experiments identified IL-23 as an effector cytokine within the innate intestinal immune system. The differential role of IL-23 in local but not systemic inflammation suggests that it may make a more specific target for the treatment of IBD. |
| Starting Page | 99 |
| Ending Page | 103 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.humgen.nl/IMDEMI/Uhlig%20et%20al%202006.pdf |
| Alternate Webpage(s) | https://www.humgen.nl/IMDEMI/Uhlig%20et%20al%202006.pdf |
| PubMed reference number | 16919486v1 |
| Volume Number | 25 |
| Issue Number | 2 |
| Journal | Immunity |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Colitis Immune system Inflammatory Bowel Diseases Interferon Type II Interleukin-12 Subunit p35 Intestinal Diseases Intestinal Wall Tissue Intestines Irritable Bowel Syndrome Leukemia, B-Cell Mucous Membrane Recombinant Interleukin-12 Tumor Necrosis Factors Wasting Syndrome cytokine production immunopathology specialty inflammatory response interleukin-23 |
| Content Type | Text |
| Resource Type | Article |
