Differences in Immunophenotyping of Mucosal Lymphocytes Between Ulcerative Colitis and Crohn’s Disease

Content Provider	Semantic Scholar
Author	Lee, Heung Bum Kim, Jong Hun Yim, Chang Yeol Kim, Dae Ghon Ahn, Deuk Soo
Copyright Year	1997
Abstract	OBJECTIVES Immunologic studies have characterized the numbers and types of inflammatory cells in diseased inflammatory bowel disease (IBD) mucosa but have yielded conflicting results regarding intestinal lymphocytes activation in IBD. We investigated the levels of lymphocytes subsets, interleukin-2 receptor, transferrin receptor, and T cell receptors in mainly isolated lamina propria lymphocytes. Including intraepithelial lymphocytes of normal colonic mucosa or IBD (ulcerative colitis and Crohn's disease) mucosa to understand the pathogenesis of IBD. We have results from this study. RESULTS 1) In comparing ulcerative colitis with control, IL-2R (p < 0.05), TR (p < 0.01), and CD3/HLA-DR (< 0.05) showed a significant increase. 2) In comparing Crohn's disease with control, CD3 (P < 0.05), TCR alpha/beta (p < 0.01) and TCR gamma/delta (p < 0.05) showed a significant decrease. 3) In comparing Crohn's disease with ulcerative colitis, CD19 (p < 0.01), TR (p < 0.01), TCR alpha/beta (p < 0.01) and TCR gamma/delta (p < 0.05) showed a significant decrease. CONCLUSION From these results, there are increased T cell markers, IL-2R, TR, and CD3/HLA-DR in UC, but differently, decreased CD3, TCR alpha/beta and TCR gamma/delta in CD compared with control. In addition, definitive differences in lymphocytes markers, CD19, TR, TCR alpha/beta and TCR gamma/delta, which are higher in UC than in CD, may elucidate the different immunopathogenesis between UC and CD.
Starting Page	7
Ending Page	15
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/3a/d9/kjim-12-1-7-2.PMC4531961.pdf
PubMed reference number	9159031v1
Volume Number	12
Journal	The Korean journal of internal medicine
Language	English
Access Restriction	Open
Subject Keyword	Chronic Lymphocytic Leukemia Crohn Disease HLA-DR Ag:Type:Pt:Tiss:Nom Hawthorn leaf with flower extract Inflammatory Bowel Diseases Interferon Type II Interleukin 2 Receptor Interleukin Receptor Common gamma Subunit Intestinal Diseases Intestines Irritable Bowel Syndrome Lamina Propria Mucous Membrane Receptors, Cell Surface Recombinant Interleukin-2 T-Cell Receptor gamma-Chain T-cell receptor complex location TCR gamma delta Ag:PrThr:Pt:Tiss:Ord:Immune stain Ulcer Ulcerative Colitis alpha-beta T-Cell Receptor type I interferon receptor
Content Type	Text
Resource Type	Article