Analysis of the association of single nucleotide polymorphisms of interleukin-23 receptor (IL-23R) and inflammatory bowel disease in a Chinese Han cohort

Content Provider	Semantic Scholar
Author	Chen, Zhi-Rong Zhu, J. B. Xu, Ya Xian Hua, Xian Ping
Copyright Year	2016
Abstract	Inflammatory bowel disease (IBD) is a chronic, complex genetic disease with rapidly increasing prevalence in China. The interactions of genetic, environmental, and microbial factors contribute to the development of IBD, however, the precise etiologies of IBD are not well understood yet. Interleukin-23 receptor (IL-23R) encodes a subunit of receptor for IL-23, which is an important proinflammatory cytokine. In this study, we investigated the relationship between the single nucleotide polymorphism (SNP) of IL-23R gene and IBD in Chinese Han population. We genotyped three nonsynonymous IL-23R SNPs with amino acid changes (rs11209026, p.Arg381Gln; rs41313262 p.Val362Ile and rs11465797 p.Thr175Asn) in 198 patients with IBD (124 UC and 74 CD) and 100 healthy controls. The prevalence of the A allele in IL-23R Arg381Gln of CD appeared less than controls, but it was not statistically significant (2.70% vs. 6.00%, p > 0.05). There was no statistical difference between UC and controls (5.65% vs. 6.00%, p = 0.91). The p.Val362Ile variant was present in 2.42% of UC patients, in 2.70% of CD patients, which was similar in the control (2.00%). There was no statistical difference among these three groups. We did not detect Thr175Asn (rs11465797 c.524 C>A) in all the three groups. In conclusion, our study demonstrated that the p.Val362Ile and Arg381Gln were not associated with susceptibility to IBD in Chinese Han population.
Starting Page	67851
Ending Page	67856
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=12296&path%5B%5D=38930
PubMed reference number	27765927v1
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.12296
DOI	10.18632/oncotarget.12296
Journal	Oncotarget
Volume Number	7
Language	English
Access Restriction	Open
Subject Keyword	Amino Acids Genetic Polymorphism Hereditary Diseases IL23R gene Inflammatory Bowel Diseases Interleukin Receptor Common gamma Subunit Intestinal Diseases Intestines Irritable Bowel Syndrome Nucleotides Parathyroid Hormone Receptor Patients Single Nucleotide Polymorphism Single-Chain Antibodies cytokine interleukin-23 binding activity interleukin-23 receptor activity
Content Type	Text
Resource Type	Article