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Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Marjoram, Lindsay Bagnat, Michel |
| Copyright Year | 2015 |
| Abstract | Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward genetics highlight the need for new model systems for disease onset characterization. Zebrafish represent a powerful platform to model IBD using forward and reverse genetics, live imaging of transgenic lines and physiological assays. In this review, we address current models of IBD in zebrafish and newly developed reagents available for future studies. |
| Starting Page | 147 |
| Ending Page | 153 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 4520400 |
| Volume Number | 3 |
| Journal | Current pathobiology reports |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Crohn Disease Infection Inflammatory Bowel Diseases Intestinal Diseases Intestines Morbidity - disease rate Reagents Reverse Genetics Ulcer Ulcerative Colitis Zebrafish |
| Content Type | Text |
| Resource Type | Article |
