Loading...
Please wait, while we are loading the content...
Similar Documents
Pulse cyclophosphamide therapy for inflammatory bowel disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Barta, Zsolt Tóth, Lászlo Zeher, Margit |
| Copyright Year | 2006 |
| Abstract | AIM To assess the efficacy of intravenous cyclophosphamide pulse therapy for refractory inflammatory bowel disease (IBD). METHODS We included in our cohort eight patients with (moderate/severe) steroid refractory IBD (4 with ulcerative colitis and 4 with Crohn's disease). They all received 6 cycles of intravenous cyclophosphamide (800 mg) per month. RESULTS Patients entered into remission after the second/third cyclophosphamide pulse. Disease activity decreased. There were no side effects and toxicity. All the patients went into long lasting remission. All Crohn's disease patients and 3 of 4 ulcerative colitis patients achieved complete remission. One patient with ulcerative colitis showed an impressive clinical response but did not enter into remission. For the maintenance, patients with Crohn's disease were treated with methotrexate (15 mg/wk) and patients with ulcerative colitis were treated with azathioprine (2.5 mg/kg body weight/d). CONCLUSION Remission was maintained in all patients for 6 mo on the average. The drug was well tolerated. These findings suggest that aggressive immunosuppressive therapy may be useful in some refractory patients and further controlled study should be considered in order to fully evaluate this type of treatment as a potential therapy for IBD. |
| Starting Page | 1799 |
| Ending Page | 1808 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://dea.lib.unideb.hu/dea/bitstream/handle/2437/102402/postfile_up_Pulse%20cyclophosphamide%20therapy%20for%20inflammatory%20bowel.pdf?isAllowed=y&sequence=1 |
| PubMed reference number | 16534885v1 |
| Volume Number | 12 |
| Issue Number | 8 |
| Journal | World journal of gastroenterology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse effects Adverse reaction to drug Azathioprine Crohn Disease Cyclophosphamide Inflammatory Bowel Diseases Intestinal Diseases Intestines Irritable Bowel Syndrome Methotrexate Patients Steroids Therapeutic immunosuppression Ulcer Ulcerative Colitis |
| Content Type | Text |
| Resource Type | Article |
