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Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results
| Content Provider | Semantic Scholar |
|---|---|
| Author | Argüelles-arias, F. Veloz, María Fernanda Guerra Amarillo, Raúl Perea Vilches-Arenas, Angel Laria, Luisa Castro Pérez, Belén Maldonado Benallal, Dina Chaaro Roldán, Antonio Benítez Merino, Vicente López Ramírez, Gabriel Sebastián Díaz Calleja-Hérnandez, Miguel Ángel Álvarez, Ángel Caunedo Gómez, Manuel Romero |
| Copyright Year | 2017 |
| Abstract | BACKGROUND Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory diseases. The advent of biosimilar treatment options such as CT-P13 promises to improve the availability of biological therapy, yet real-world switching data are currently limited. Here, we assess the effectiveness and safety of switching to CT-P13 from infliximab reference product (RP) in patients with inflammatory bowel disease. MATERIALS AND METHODS This was a prospective single-center observational study in patients with moderate to severe Crohn's disease (CD) and ulcerative colitis (UC). All patients were switched from infliximab RP (Remicade) to CT-P13 treatment and followed up for up to 12 months. The efficacy endpoint was the change in clinical response assessed at 3-monthly intervals, according to the Harvey-Bradshaw score and partial Mayo score for patients with CD and UC, respectively. C-reactive protein (CRP) was also measured. Adverse events were monitored and recorded throughout the study. RESULTS A total of 98 patients with inflammatory bowel disease (67 CD/31 UC) were included. A total of 83.6% (56/67) of patients with CD were in remission at the time of the switch and 62.7% were in remission at 12 months. The Harvey-Bradshaw score showed a significant change at 12 months (P=0.007) but no significant change was observed in median CRP at this timepoint (P=0.364). A total of 80.6% (25/31) of patients with UC were in remission at the time of the switch and 65.3% (18/28) were in remission at 12 months. No significant changes in the median partial Mayo score (P=0.058) or CRP (P=0.329) were observed at 12 months. Serious adverse events related to medication were reported in 11 (11.2%) patients. CONCLUSION Switching from infliximab RP to CT-P13 is efficacious and well tolerated in patients with CD or UC for up to 12 months. |
| Starting Page | 1290 |
| Ending Page | 1295 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28902041v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MEG.0000000000000953 |
| DOI | 10.1097/MEG.0000000000000953 |
| Journal | European journal of gastroenterology & hepatology |
| Volume Number | 29 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse event Antineoplastic Agents Crohn Disease Inflammatory Bowel Diseases Intestinal Diseases Intestines Patients Ulcer Ulcerative Colitis infliximab |
| Content Type | Text |
| Resource Type | Article |
