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The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lewis, James D. |
| Copyright Year | 2011 |
| Abstract | Fecal and serologic biomarkers can be used in the diagnosis and management of inflammatory bowel disease (IBD). Fecal markers such as calprotectin and lactoferrin have been studied for their ability to identify patients with IBD, assess disease activity, and predict relapse. Antibodies against Saccharomyces cerevisiae and perinuclear antineutrophil cytoplasmic proteins have been used in diagnosis of IBD, to distinguish Crohn's disease (CD) from ulcerative colitis, and to predict the risk of complications of CD. Tests for C-reactive protein and erythrocyte sedimentation rate have been used to assess inflammatory processes and predict the course of IBD progression. Levels of drug metabolites and antibodies against therapeutic agents might be measured to determine why patients do not respond to therapy and to select alternative treatments. This review addresses the potential for biomarker assays to improve treatment strategies and challenges to their use and development. |
| Starting Page | 517 |
| Ending Page | 529 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.fluidsiq.com/pdfs/Lewis_Bowel%20Dis_%20Calprotectin_2011.pdf |
| PubMed reference number | 21530748v1 |
| Alternate Webpage(s) | https://doi.org/10.1053/j.gastro.2010.11.058 |
| DOI | 10.1053/j.gastro.2010.11.058 |
| Journal | Gastroenterology |
| Volume Number | 140 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biological Markers Blood Sedimentation Crohn Disease Erythrocytes Inflammatory Bowel Diseases Intestinal Diseases Intestines Irritable Bowel Syndrome Leukocyte L1 Antigen Complex Patients Ulcer Ulcerative Colitis |
| Content Type | Text |
| Resource Type | Article |
