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Vitamin D 3 supplementation for 8 weeks leads to improved haematological status following 1 the consumption of an iron-fortified breakfast cereal : a double-blind randomised controlled 2 trial in iron-deficient women . ( 1-2 ) 3 4
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fuzi, Salma F. Ahmad Mushtaq, Sohail |
| Copyright Year | 2019 |
| Abstract | 36 The effect of 38 μg (1500 IU) daily vitamin D3 supplementation, consumed with an iron-fortified 37 breakfast cereal for 8 weeks, on haematological indicators in iron-deficient female subjects was 38 investigated. Fifty iron-deficient subjects (plasma ferritin concentration < 20 μg/L; mean age ± SD: 39 27.4 ± 9.4 years) were randomised to consume an iron-fortified breakfast cereal containing 9 mg of 40 iron daily, with either a vitamin D3 supplement or placebo. Blood samples were collected at 41 baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of iron and vitamin D 42 status biomarkers. The effect of intervention was analysed using mixed-model repeated measures 43 ANOVA. Significant increases were observed in two main haematological indices: haemoglobin 44 concentration and haematocrit level from baseline to post-intervention in the vitamin D group, but 45 not in the placebo group. The increase from baseline to post-intervention in haemoglobin 46 concentration in the vitamin D group (135 ± 11 to 138 ± 10 g/L) was significantly higher compared 47 to the placebo group (131 ± 15 to 128 ± 13 g/L) (P=0.037). The increase in haematocrit level from 48 baseline to post-intervention was also significantly higher in the vitamin D group (42.0 ± 3.0 to 43.8 49 ± 3.4%) compared to the placebo group (41.2 ± 4.3 to 40.7 ± 3.6%) (P=0.032). Despite the non50 significant changes in plasma ferritin concentration, this study demonstrates that 38 μg 51 supplemental vitamin D, consumed daily, with iron-fortified breakfast cereal led to improvement in 52 haemoglobin concentration and haematocrit levels in women with low iron stores. These findings 53 may have therapeutic implications in the recovery of iron status in iron-deficient populations at a 54 healthcare level. 55 INTRODUCTION 56 Combatting anaemia or iron deficiency requires a cohesive approach, as its occurrence is 57 suggested to be multifactorial. Iron supplements have been widely used to correct iron deficiency in 58 at-risk groups, whereas in the general population either modification of the diet or iron fortification 59 in selected food vehicles may be implemented (1) . Dietary modification requires long-term 60 objectives, and evidence from recent experimental trials has shown that iron fortification, which is 61 considered a medium-term strategy (2) , will not completely improve general iron status, whilst the 62 efficacy of oral iron supplementation in improving iron status is often limited by low adherence as a 63 result of adverse events following supplementation (3) . The measurement of different iron 64 parameters is fundamental to determining of iron status, due to a broad spectrum which extends 65 between iron deficiency and iron overload, which both occur due to the failure of iron homeostasis 66 and causes flaws at functional and structural levels (4) . The presence of anaemia can be confirmed 67 with a single biomarker of haemoglobin concentration, whilst measurement of ferritin concentration 68 D ow nladed fom hts://w w w am bridorg/core . Egene M cD rm tt Lirary, U nirsity of Txas at D allas , on 02 M ar 2019 at 1349:50 , suject to he am bidge Core term s of use, avilable at hts://w w w am bridgeg/core/term s . https://doi.org7/S0007114519000412 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://vitamindwiki.com/tiki-download_wiki_attachment.php?attId=11492&download=y |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
