NDLI: Vitamin $D_{3}$ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

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Vitamin $D_{3}$ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Content Provider	Scilit
Author	Fuzi, Salma F. Ahmad Mushtaq, Sohail
Copyright Year	2019
Description	The effect of 38 µg (1500 IU) daily vitamin $D_{3}$ supplementation, consumed with an Fe-fortified breakfast cereal for 8 weeks, on haematological indicators in Fe-deficient female subjects was investigated. Fifty Fe-deficient subjects (plasma ferritin concentration <20 µg/l; mean age: 27·4 (sd 9·4) years) were randomised to consume an Fe-fortified breakfast cereal containing 9 mg of Fe daily, with either a vitamin $D_{3}$ supplement or placebo. Blood samples were collected at baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of Fe and vitamin D status biomarkers. The effect of intervention was analysed using mixed-model repeated-measures ANOVA. Significant increases were observed in two main haematological indices: Hb concentration and haematocrit level from baseline to post-intervention in the vitamin D group but not in the placebo group. The increase from baseline to post-intervention in Hb concentration in the vitamin D group (135 (sd 11) to 138 (sd 10) g/l) was significantly higher compared with the placebo group (131 (sd 15) to 128 (sd 13) g/l) (P=0·037). The increase in haematocrit level from baseline to post-intervention was also significantly higher in the vitamin D group (42·0 (sd 3·0) to 43·8 (sd 3·4) %) compared with the placebo group (41·2 (sd 4·3) to 40·7 (sd 3·6) %) (P=0·032). Despite the non-significant changes in plasma ferritin concentration, this study demonstrates that 38 µg supplemental vitamin D, consumed daily, with Fe-fortified breakfast cereal led to improvement in Hb concentration and haematocrit levels in women with low Fe stores. These findings may have therapeutic implications in the recovery of Fe status in Fe-deficient populations at a healthcare level.
Related Links	https://chesterrep.openrepository.com/bitstream/10034/622082/1/vitamin_d3_supplementation_for_8_weeks_leads_to_improved_haematological_status_following_the_consumption_of_an_ironfortified_breakfast_cereal_a_doubleblind_randomised_controlled_trial_in_irondeficient_women_12.pdf https://www.cambridge.org/core/services/aop-cambridge-core/content/view/BF1FD0291A110FF2D488064EF4A2BF40/S0007114519000412a.pdf/div-class-title-vitamin-d-span-class-sub-3-span-supplementation-for-8-weeks-leads-to-improved-haematological-status-following-the-consumption-of-an-iron-fortified-breakfast-cereal-a-double-blind-randomised-controlled-trial-in-iron-deficient-women-1-2-div.pdf
Ending Page	1157
Page Count	12
Starting Page	1146
ISSN	00071145
e-ISSN	14752662
DOI	10.1017/s0007114519000412
Journal	British Journal of Nutrition
Issue Number	10
Volume Number	121
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2019-03-01
Access Restriction	Open
Subject Keyword	British Journal of Nutrition hydroxyvitamin D Hamp Antimicrobial Peptide Mch Mean Corpuscular Hb Pth Parathyroid Hormone high Temperature Vdbp Vitamin D Binding Protein Stfr Soluble Transferrin Receptor Iron Status fortified Cereals Vitamin D Supplementation
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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Vitamin $D_{3}$ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

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