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Hypoperfusion and vasoreactivity in the thalamus and cerebellum after stroke.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sakashita, Yoko Matsuda, Hiroshi Kakuda, Kiyoshi Takamori, Masaharu |
| Copyright Year | 1993 |
| Abstract | BACKGROUND AND PURPOSE Cerebellar hypoperfusion in the contralateral hemisphere after stroke is well studied and termed crossed cerebellar diaschisis. However, studies of hypoperfusion in the ipsilateral thalamus have been few. The purpose of this study was to investigate the prevalence of hypoperfusion and vasoreactivity to acetazolamide in the thalamus and cerebellum after stroke. METHODS We studied cerebral blood perfusion in the thalamus and cerebellum of 14 patients with unilateral cerebral infarction using [123I]isopropyliodoamphetamine single-photon emission computed tomography (123I-IMP SPECT). We also administered acetazolamide-stressed 123I-IMP SPECT to determine vasodilator capacity in these two areas. Regions of interest were drawn over the bilateral thalami and bilateral cerebellar cortices, and asymmetry indexes were obtained. RESULTS We found ipsilateral thalamic hypoperfusion in 12 (85.7%) and contralateral cerebellar hypoperfusion in 11 (78.6%) of 14 patients. Hypoperfusion was improved (p < 0.01 by the Wilcoxon signed rank test) in 11 (91.7%) of the 12 patients with ipsilateral thalamic hypoperfusion and in seven (63.6%) of the 11 patients with contralateral cerebellar hypoperfusion. CONCLUSIONS Hypoperfusion in the ipsilateral thalamus and contralateral cerebellum is common, and vasoreactivity to acetazolamide is preserved in both the thalamus and the cerebellum with hypoperfusion. |
| Starting Page | R1625 |
| Ending Page | R1628 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/24/1/84.full.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/24/1/84.full.pdf?download=true |
| PubMed reference number | 8418556v1 |
| Volume Number | 24 |
| Issue Number | 1 |
| Journal | Stroke |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetazolamide Biologic Preservation Cerebellar Diseases Cerebral Infarction Cerebrovascular accident Cortical Cell Layer of the Cerebellum Index Midline Thalamic Nuclei Patients Photons Posterior Thalamic Nuclei Thalamic structure Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon Vasodilator Agents X-Ray Computed Tomography childhood cerebellar astrocytoma hypoperfusion signed - ParticipationSignature |
| Content Type | Text |
| Resource Type | Article |
