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Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Imaizumi, Masao Kitagawa, Kazuo Hashikawa, Kazuo Oku, Naohiko Teratani, Tadamasa Takasawa, Masashi Yoshikawa, Takuya Rishu, Piao Ohtsuki, Toshiho Hori, Masatsugu Matsumoto, Masayasu Nishimura, Tsunehiko |
| Copyright Year | 2002 |
| Abstract | BACKGROUND AND PURPOSE Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. In clinical practice, the detection of patients with misery perfusion through the use of widely available, noninvasive, and cost-effective modalities such as single-photon emission computed tomography (SPECT) is extremely important. METHODS We evaluated the relationships between the regional hemodynamic status of cerebral circulation, measured with split-dose [123I] N-isopropyl-p-iodoamphetamine SPECT (123I-IMP SPECT) and an acetazolamide challenge, and hemodynamic parameters, including OEF measured with PET, in 27 patients with both unilateral and bilateral carotid occlusive diseases. RESULTS A significant negative correlation was found between the SPECT-measured cerebrovascular reserve after acetazolamide administration and both the PET-measured OEF and cerebral blood volume. Neither the cerebrovascular reserve nor the cerebral blood flow index, when expressed as a SPECT-measured cerebrum-to-cerebellum ratio, was useful for detecting lesions with an elevated OEF. However, a combination of the cerebrovascular reserve and cerebral blood flow index showed high sensitivity, specificity, and positive predictive value for the detection of misery perfusion. CONCLUSIONS Our study suggests that split-dose 123I-IMP SPECT with an acetazolamide challenge could be useful for screening patients with misery perfusion in carotid occlusive diseases. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/33/9/2217.full.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/33/9/2217.full.pdf?download=true |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/33/9/2217.full.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/33/9/2217.full.pdf?origin=publication_detail |
| PubMed reference number | 12215590v1 |
| Volume Number | 33 |
| Issue Number | 9 |
| Journal | Stroke |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetazolamide Carotid Artery Diseases Carotid Stenosis Cerebellum Cerebral Blood Volume Cerebral Ischemia Cerebrovascular Circulation Cerebrovascular accident Chemotherapy, Cancer, Regional Perfusion Hemodynamics Infusion Pumps, Implantable Iofetamine Oxygen Patients Photons Positive Predictive Value of Diagnostic Test Positron-Emission Tomography Positrons Stage level 2 Tomography, Emission-Computed Tracer Extraction Fraction X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Article |
