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Downregulation of drs mRNA expression is associated with the progression of adult T-cell leukemia/lymphoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shimakage, Misuzu Inoue, Nobumasa Ohshima, Kohichi Kawahara, Kunimitsu Yamamoto, Naoki Oka, Takashi Tambe, Yukihiro Yasui, Kazuta Matsumoto, Kayoko Yutsudo, Masuo Inoue, Hirokazu |
| Copyright Year | 2007 |
| Abstract | Although adult T-cell leukemia/lymphoma (ATLL) is initiated by infection with human T-cell leukemia virus (HTLV-1), many other factors are thought to be required for the progression from indolent ATL to aggressive ATLL. The drs gene was originally isolated as a novel suppressor gene of v-src transformation and was shown to induce apoptosis in human cancer cells. To investigate the involvement of drs downregulation in the progression of ATLL, we examined the expression of drs in smoldering, chronic and aggressive ATLL, and found that drs expression was markedly reduced in clinically aggressive ATLL. In aggressive ATLL cell lines, expression of drs mRNA was not detected, although expression of drs mRNA was detected in T-cell lines infected with HTLV-1. A correlation between drs downregulation and expression of the Tax gene was not observed in these T-cell lines. Furthermore, introduction of drs into an ATL cell line, HUT102, by retrovirus vector suppressed the colony formation of the cells in soft agar and enhanced apoptotic cell death of the cells under low serum culture conditions. These results indicate that downregulation of drs is closely linked to the progression of ATLL, independently of Tax expression, suggesting that drs may suppress the progression of ATLL via enhancing apoptosis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ijo/30/6/1343/download |
| PubMed reference number | 17487354v1 |
| Volume Number | 30 |
| Issue Number | 6 |
| Journal | International journal of oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adult T-Cell Lymphoma/Leukemia Apoptosis Cell Death Cellular Phone Down-Regulation Human T-lymphotropic virus 1 Leukemia, B-Cell Leukemia, T-Cell Lymphoma T-Lymphocyte leukemia |
| Content Type | Text |
| Resource Type | Article |
