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Effect of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on food-anticipatory activity rhythm in the rat
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ono, Michiko Shibata, Shigenobu Minamoto, Yoshitsugu Watanabe, Shigenori |
| Copyright Year | 1996 |
| Abstract | When feeding was restricted to a single meal scheduled at a fixed time (1300-1700 h) in the day, rats exhibited increased prefeeding locomotor activity 1-3 h before the feeding time, which increased over 6 days. The activity increase was seen for about 5 h (1100-1600 h) on the seventh day when no food was provided (fasting day), as the rat anticipated mealtime. Thus, mealtime-associated activity rhythm on the fasting day was considered to be another good index of food-anticipatory activity. In this study, we investigated the effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, which has been reported to cause impairment of spatial learning, on food-anticipatory activity in rats. Daily injection of MK-801 (0.2 mg/kg) at 1700 h for 6 successive days impaired the development of increased prefeeding activity. The appearance of mealtime-associated activity was impaired by daily injection of MK-801 (0.2 mg/kg) at 1700 h (immediately after food restriction, FR) or at 1900 h (2 h after FR) but not at 0900 (16 h after FR). In addition, mealtime-associated activity was impaired by MK-801 injected at 1700 h in a dose-dependent manner (0.1-1 mg/kg). The present results demonstrate that NMDA receptor mechanisms were involved in learning processes of food anticipation and suggest that an impairment of food-anticipatory activity may be considered an animal model of a deficit of "temporal learning". |
| Starting Page | 585 |
| Ending Page | 589 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0031-9384(95)02115-9 |
| PubMed reference number | 8778838 |
| Journal | Medline |
| Volume Number | 59 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0031938495021159 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0031938495021159?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0031-9384%2895%2902115-9 |
| Journal | Physiology & Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
