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The specific N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 blocks U-50,488, but not morphine antinociception
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kest, Benjamin Marek, Przemyslaw Liebeskind, John C. |
| Copyright Year | 1992 |
| Abstract | The effect of the specific NMDA receptor antagonist MK-801 on antinociception produced by the kappa opiate receptor agonist U-50,488 and the mu receptor agonist morphine was assessed using the tail-flick test in rats. MK-801 (0.05 and 0.1 mg/kg) antagonized antinociception induced by all three doses of U-50,488 (7.5, 15 and 30 mg/kg), and potentiated antinociception induced by the lower (1 mg/kg) but not higher (5 mg/kg) dose of morphine. Naloxone at a dose of 1.0 but not 0.1 mg/kg blocked U-50,488 antinociception, indicating that MK-801 affects opiate antinociception. The present results are the first to suggest a critical role for the NMDA receptor in opiate antinociception involving the kappa receptor. |
| Starting Page | 139 |
| Ending Page | 142 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(92)91173-C |
| PubMed reference number | 1422813 |
| Journal | Medline |
| Volume Number | 589 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/000689939291173C |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/000689939291173C?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2892%2991173-C |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
