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The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits
| Content Provider | Semantic Scholar |
|---|---|
| Author | Scheller, Mark S. Zornow, Mark H. Fleischer, Jennifer Shearman, Gary Terence Greber, T. F. |
| Copyright Year | 1989 |
| Abstract | Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia. |
| Starting Page | 677 |
| Ending Page | 681 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0028-3908(89)90150-0 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0028390889901500 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0028390889901500?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 2548110 |
| Alternate Webpage(s) | https://doi.org/10.1016/0028-3908%2889%2990150-0 |
| Journal | Medline |
| Volume Number | 28 |
| Journal | Neuropharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
