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Effects of N-methyl-d-aspartate (NMDA) antagonist MK-801 on breathing pattern in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Monteau, Roger Gauthier, Patrick Rega, Paul Hilaire, G. |
| Copyright Year | 1990 |
| Abstract | In anaesthetized, bivagotomized and artificially ventilated rats, the respiratory effects of systemic injection of MK-801, a non-competitive N-methyl-D-aspartate antagonist, were studied. In all the experiments (n = 11), the injection increased the inspiratory duration and decreased the expiratory duration. In 4 experiments, the inspiratory duration was drastically lengthened, resulting in an apneustic-like breathing pattern. These results demonstrate that apneusis is difficult but possible to induce in rats and suggest that termination of inspiration is controlled via central mechanisms in which NMDA-like receptors are involved. |
| Starting Page | 134 |
| Ending Page | 139 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(90)90551-J |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409090551J |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409090551J?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 2156189 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2890%2990551-J |
| Journal | Medline |
| Volume Number | 109 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
