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Viral aetiology of adult T-cell leukaemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yamamoto, Naoki Hinuma, Yorio |
| Copyright Year | 1985 |
| Abstract | RNA tumour viruses (retroviruses) have been implicated as the causal agents of many naturally occurring neoplasms such as sarcomas, leukaemias, malignant lymphomas and carcinomas in various animal species (Aaronson & Stephenson, 1976; Hardy et al., 1980). Evidence for an involvement of retroviruses in human malignancies, however, has been obtained only very recently. In 1980 and 1981, human T-cell leukaemia virus (HTLV) and adult T-cell leukaemia (ATL) virus (ATLV) were isolated independently in the U.S.A. from an aggressive type of T-cell malignancy and in Japan from a patient with ATL, respectively (Poiesz et al., 1980, 1981 ; Hinuma et aL, 1981 ; Yoshida et aL, 1982). Both viruses exhibited close similarities to the hitherto known animal retroviruses but were different structurally and immunologically (Rho et al., 1981 ; Reitz et al., 1981 ; Kalyanaraman et al., 1981). These two viruses quickly attracted the attention of a number of virologists and haematologists and the aetiological role of these viruses in mature T-cell malignancy was investigated extensively. Sufficient results accumulated to suggest that the viruses were indistinguishable (Watanabe et al., 1984; Yoshida et al., 1984). Though ATL represents only a minor fraction of all human malignancies it is extremely important that a retrovirus has been found which may cause a human malignancy. The discovery of HTLV/ATLV and the determination of its causal role in ATL provides an invaluable model for investigation of human malignancies by various means, e.g. the therapy and immunoprevention of leukaemia, and the possible involvement of viruses in other human malignancies. |
| Starting Page | 57 |
| Ending Page | 63 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jgv/66/8/JV0660081641.pdf?accname=guest&checksum=9CD280633A559EF45DDFABACA80A324D&expires=1540417535&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jgv/66/8/JV0660081641.pdf?accname=guest&checksum=1FFAF6281C0CD932AB27CA96DDC44394&expires=1543411379&id=id |
| PubMed reference number | 2991434v1 |
| Volume Number | 66 |
| Part | 8 |
| Journal | The Journal of general virology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adult T-Cell Lymphoma/Leukemia Carcinoma Cellular Phone Chronic Lymphocytic Leukemia Human T-lymphotropic virus 1 Leukemia, B-Cell Lymphoma Neoplasms Patients RNA Retroviridae Sarcoma T-Lymphocyte |
| Content Type | Text |
| Resource Type | Article |
