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Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Marchesi, Simona Denise Lupattelli, Graziana Schillaci, Giuseppe Pirro, Matteo Siepi, Donatella Roscini, Anna Rita Pasqualini, Leonella Mannarino, Elmo |
| Copyright Year | 2000 |
| Abstract | Impaired flow-mediated vasodilation in large arteries is an expression of endothelial dysfunction and an established marker of early atherosclerosis. Post-prandial lipemia can induce an impairment of the endothelial function. The aim of our study was to evaluate the effects of post-prandial phase on flow-mediated vasodilation in a group of ten young (23 +/- 2 years) healthy men without cardiovascular risk factors, who underwent an oral fat-loading test. Flow-mediated vasodilation of the brachial artery and serum lipid profile were assessed under fasting conditions and 2, 4, 6 and 8 h after a high-fat meal. Triglycerides increased from 0.6 +/- 0.2 fasting to 1.1 +/- 0.5 and 1.3 +/-0.6 mmol/l at the 2nd and 4th hour (both P < 0.01), and decreased thereafter. Flow-mediated vasodilation fell significantly from 14.5 +/- 6.6% fasting to 3.5 +/- 1.5% and 4.0 +/- 2.2% at the 2nd and 4th hour (both P < 0.01), and returned to the basal values at the 6th and 8th hour. A strong inverse correlation was observed between the area under the incremental curve of post-prandial triglycerides (i.e. after subtraction of baseline triglycerides) and the area under the decremental curve of post-prandial flow-mediated vasodilation (r = -0.70, P = 0.025). No association was found between post-prandial vasodilation changes and fasting triglycerides, other lipid parameters or insulin. We conclude that a transient post-prandial impairment in brachial artery flow-mediated vasodilation is evident in young healthy men after a high-fat meal, and is closely associated with triglyceride levels. These data provide support for a role of post-prandial phase in vascular regulation in young healthy subjects. |
| Starting Page | 397 |
| Ending Page | 402 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://homertgen.files.wordpress.com/2015/09/impaired-flow-mediated-vasoactivity-atherosclerosis-2000-v153-p397-402.pdf |
| PubMed reference number | 11164429v1 |
| Volume Number | 153 |
| Issue Number | 2 |
| Journal | Atherosclerosis |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arteries Atherosclerosis Fatty acid glycerol esters Increment Lipemia - observation Millimole per Liter Platelet Glycoprotein 4, human Structure of brachial artery Triglycerides Vasodilation disorder |
| Content Type | Text |
| Resource Type | Article |
