Loading...
Please wait, while we are loading the content...
Similar Documents
Maternal diet composition alters serum steroid and free fatty acid concentrations and vaginal pH in mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Whyte, Jeff J. Alexenko, Andrei P. Davis, Antonia M. Ellersieck, Mark R. Fountain, Emily D. Rosenfeld, Cheryl S. |
| Copyright Year | 2007 |
| Abstract | We examined the effects of three maternal diets (very high fat (VHF), low fat (LF), and control (Purina 5015)) on serum steroids, free fatty acids (FFA), and vaginal pH in National Institutes of Health Swiss mice. Females were fed (VHF, n = 33; LF, n = 33; 5015, n = 48) from 4 to 16 weeks of age. Following breeding, female serum was collected at 0.5 (pre-implantation, early diestrus) or 8.5 (post-implantation, mid-diestrus) days post-coitus (dpc). The serum concentrations of 17beta-estradiol, testosterone, progesterone, and FFA were analyzed at both collection points, and vaginal pH at 0.5 dpc. Striking differences in steroids and FFA were observed at 0.5 dpc among the groups. Estradiol was higher in the VHF (14.1 +/- 3.0 pg/ml), compared with LF mice (5.2 +/- 2.3 pg/ml; P< or = 0.05). In contrast, 0.5 dpc testosterone was lower in the VHF (10.5 +/- 3.0 pg/ml) versus the LF group (32.7 +/- 8.4 pg/ml; P< or = 0.05). At 8.5 dpc, progesterone was higher in the VHF (89.6 +/- 6.7 ng/ml) versus the 5015 group (60.1 +/- 4.9 ng/ml; P< or = 0.05). VHF mice had higher FFA concentrations at 0.5 dpc (1.0 +/- 0.2 mmol/l) than LF and control mice (0.5 +/- 0.1 and 0.6 +/- 0.1 mmol/l respectively; P< or = 0.05). At 8.5 dpc, VHF females had higher serum FFA (0.8 +/- 0.1 mmol/l) than LF and control females (0.4 +/- 0.1 and 0.6 +/- 0.1 mmol/l; P< or = 0.05). Mean vaginal pH of VHF females (6.41 +/- 0.09) was lower than 5015 females (6.76 +/- 0.10; P< or = 0.05). These diet-induced alterations in serum steroid and FFA concentrations might affect several reproductive processes, including preferential fertilization by one class of sperm over the other and sex bias in pre- and post-implantational embryonic development. |
| Starting Page | 75 |
| Ending Page | 81 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://joe.bioscientifica.com/downloadpdf/journals/joe/192/1/1920075.pdf |
| PubMed reference number | 17210744v1 |
| Volume Number | 192 |
| Issue Number | 1 |
| Journal | The Journal of endocrinology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Breeding Coitus Embryonic Development Estradiol Fat-Restricted Diet Fatty acid glycerol esters Fertilization Microgram per Liter Millimole per Liter Nanogram per Liter Nonesterified Fatty Acids Platelet Glycoprotein 4, human Progesterone Reproduction Spermatozoa Cell Count Steroids Testosterone Vagina |
| Content Type | Text |
| Resource Type | Article |
