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The fatty acid patterns of plasma lipids during alimentary lipemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dole, Vincent P. James, Anthony T. Webb, James W. Rizack, Martin A. Sturman, M. F. |
| Copyright Year | 1959 |
| Abstract | The total amount of fatty acid contained in the blood stream at any moment is considerably less than the amount of fat that might be taken in a single feeding. Therefore, during the period of alimentary lipemia some of the lipids in blood would be expected to acquire the composition of dietary fat. To illustrate, the blood plasma of a 70 Kg. man contains about 50 mEq. of fatty acids (approximately 25 mEq. in phospholipids, 12 mEq. in cholesterol esters, 10 mEq. in triglycerides and 3 mEq. in nonesterified fatty acids), whereas a meal containing 3 ounces of fat provides 300 mEq. The amount of fatty acid entering the blood during a period of a few hours after such a feeding thus is about six times the total amount in circulation and, since the concentration of fatty acid in plasma remains approximately constant during absorption, the fatty acids of plasma must turn over on the average about six times. The actual turnover of transport lipids must be much greater than this since only a small part of the plasma lipid participates directly in absorption. Practically all of the newly absorbed fat enters the blood as triglyceride (1, 2). If dietary fat were simply mixed with this small pool and then transported to the tissues, the pool would turn over about 30 times and the composition of plasma triglyceride would become identical with that of dietary fat during the period of absorption. Some evidence of this expected effect was obtained by Wilson and Hanner (3) who fed large doses of cream or cod liver oil to children and observed that the iodine number of the increment of blood lipids during the lipemic phase became approximately equal to the iodine number of the fed fat. It is also known that the composition of |
| Starting Page | 197 |
| Ending Page | 203 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/103000/103933/JCI59103933.pdf |
| PubMed reference number | 13817285v1 |
| Volume Number | 38 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body tissue Cholesterol Cod Liver Oil Contain (action) Dietary Fats Fatty acid glycerol esters Gastrointestinal tract structure Hematological Disease Increment LIPOPROTEIN LIPASE Lipemia - observation Lipemic Index Lipids measurement Nonesterified Fatty Acids Phospholipids Plasma Platelet Glycoprotein 4, human Triglycerides ounce |
| Content Type | Text |
| Resource Type | Article |
