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Osteonecrose associada aos bifosfonatos na odontologia - revisão de literatura
| Content Provider | Semantic Scholar |
|---|---|
| Author | Teixeira, Nádia Nara Soares Moreira, Geane |
| Copyright Year | 2011 |
| Abstract | Introduction: Bisphosphonates are analogous to endogenous pyrophosphates and present high affinity with mineralized tissues, acting on sites with large bone formation and resorption. Bisphosphonates are used for the treatment of osteoporosis, osteogenesis imperfecta, fibrous dysplasia, Paget’s disease, multiple myeloma and bone metastases form various types of malignant neoplasias.However, several complications from their use have been described, especially osteonecrosis of gnathic bones. This disorder may be similar to those found in other pathologies, like osteoradionecrosis and osteomyelite. objectives: The aims of this literature review were to identify the possible involved mechanisms in the etiopatogenesis, the clinical manifestations, as well as protocols of prevention, diagnosis and treatment for osteonecrosis of gnathic bones. Revision of Literature: It was reported that osteonecrosis caused by bisphosphonates is more often in patients with multiple myeloma and breast cancer, although it has also been reported in patients treated for osteoporosis. The etiology of this condition has been suggested as being a relationship between tooth extractions and periodontal alterations, even though there have been reports of apparently spontaneous cases. In spite of the severity of this pathology, there are no established treatment protocols. The treatment options range from conservative treatments using antibiotics and chlorhexidine mouthrinses, to radical treatments like mandibulectomy and maxillectomy. Alternative treatments may also be performed, using platelet-rich plasma associated with bone resections. Conclusion: Due to effects of bisphosphonates on the gnathic bones, the emphasis should be on prevention, with clinical and radiographic examinations for detection of possible dental infections and perform the required procedures, like tooth extractions and endodontic and periodontal treatments, as well as removal of mandibular or maxillary tori, which are one of the most affected anatomic areas. Dental protocols prior to bisphosphonate therapy should be routine at the beginning of the medical treatment as a means to prevent osteonecrosis. |
| File Format | PDF HTM / HTML |
| Volume Number | 40 |
| Alternate Webpage(s) | http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-4-artigo-11.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
