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Isolation of Pseudomonas aeruginosa coproducing metallo-β-lactamase SPM-1 and 16S rRNA methylase RmtD1 in an urban river.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fontes, Livia De Carvalho Neves, Patricia Rodrigues A. Oliveira, Silvane Terezinha De Silva, Ketrin Cristina Da Hachich, Elayse Maria Sato, María Inés Zanoli Lincopan, Nilton |
| Copyright Year | 2011 |
| Abstract | Pseudomonas aeruginosa (strain 48-1997A) producing Sao Paulo metallo-beta-lactamase (MBL)-1 (SPM-1) was described for the first time in 1997 and came from a 4-year-old leukemic girl in Sao Paulo, Brazil (15). Since then, SPM-1-producing P. aeruginosa has become endemic in Brazilian hospitals, being recurrently associated with outbreaks of nosocomial infection (8, 11, 12). More recently, the first reports of the MBL SPM-1 were described in Europe (14) and western Asia (GenBank accession no. {"type":"entrez-nucleotide","attrs":{"text":"HM370523.1","term_id":"307949947","term_text":"HM370523.1"}}HM370523.1), denoting the potential for SPM-1 to become endemic worldwide (6). Unfortunately, carbapenem-resistant P. aeruginosa isolates carrying the SPM-1 enzyme have exhibited additional resistance to aminoglycosides, which has been mediated by a novel 16S rRNA methylase defined as RmtD (3), rendering ineffective a potent double-coverage regimen of a carbapenem plus an aminoglycoside and contributing to the emergence of panresistant phenotypes (3, 4). In this letter, we report the first environmentally isolated Pseudomonas aeruginosa carrying the blaSPM-1 and rmtD1 genes, providing additional data on the epidemiology of these genetic determinants of resistance. |
| Starting Page | 1357 |
| Ending Page | 1359 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://aac.asm.org/content/early/2011/04/04/AAC.00138-11.full.pdf |
| PubMed reference number | 21464240v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/AAC.00138-11 |
| DOI | 10.1128/AAC.00138-11 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume Number | 55 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Accession Number (identifier) Amikacin Aminoglycosides Animals, Inbred Strains Antibiotic Resistance, Microbial Aztreonam Biopolymer Sequencing Carbapenems Cefotaxime Ceftazidime Ciprofloxacin Community Cumulative Trauma Disorders GenBank Genetic Background Gentamicins Imipenem Infections, Hospital Largest Levofloxacin Methyltransferase Phenotype Polymyxin B Polymyxins Pseudomonas aeruginosa Ab:ACnc:Pt:Ser:Qn Reservoir Device Component Sulfamethoxazole Tobramycin Trimethoprim-Sulfamethoxazole Combination beta Thalassemia beta-Lactamase cefepime ertapenem meropenem piperacillin-tazobactam combination statistical cluster tazobactam |
| Content Type | Text |
| Resource Type | Article |
