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Extended-spectrum beta-lactamase-producing Salmonella enteritidis in Trinidad and Tobago.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Singh, Nalini Charles, William Prabhakar, Pradeep |
| Copyright Year | 1999 |
| Abstract | To the Editor: Salmonella Enteritidis, a predominantly localized pathogen of the human gastrointestinal tract, can become invasive in very young, very old, malnourished, and immunocompromised patients. In recent years, S. Enteritidis has emerged as a major intestinal pathogen in Trinidad and Tobago (population 1.2 million); in 1997, S. Enteritidis caused 79 (66%) of 119 culture-confirmed salmonella infections, in contrast to 18 (18%) of 99, 48 (47%) of 102, and 107 (61%) of 178 in 1994, 1995, and 1996, respectively. Increased incidence of S. Enteritidis infections has been reported worldwide (1,2). Of 216 human S. Enteritidis isolates tested for antimicrobial susceptibility between 1994 and 1996 in Trinidad, none were resistant to cephalosporins, aminoglycosides, ampicillin, trimethoprim-sulphamethoxazole, chloramphenicol, and norfloxacin/ciprofloxacin by the KirbyBauer disk diffusion method, which uses the National Committee for Clinical Laboratory Standards (NCCLS) breakpoints (3). Here we report an unusual isolate of S. Enteritidis resistant to all penicillins and cephalosporinsincluding third-generation cephalosporins, gentamicin, tobramicin, and trimethoprim-sulphamethoxazoleby the KirbyBauer disk diffusion method. Amoxicillinclavulanate and piperacillin-tazobactam disks gave zone sizes of 15 mm and 19 mm, respectively, which are classified as intermediate in the NCCLS guidelines. This isolate was recovered from the blood culture of a febrile, nonneutropenic patient with multiple myeloma on two occasions 24 hours apart in March 1998. The isolate was sensitive only to ofloxacin and imipenem. Admitted to the hospital with compressed fracture of the spine for physiotherapy in December 1997, the patient had several febrile episodes and received several courses of multiple empirically prescribed antibiotics (cefotaxime, gentamicin, and piperacillin). The patient had not traveled abroad during the previous 6 months. Because cephalosporin resistance in salmonellae has not been reported before in the Caribbean, we investigated the mechanism behind this third-generation cephalosporin resistance further. Using amoxicillin-clavulanate in combination with ceftazidime, ceftriaxone, and aztreonam, we performed the double disk synergy test to determine whether this strain was an extended-spectrum beta-lactamase producer as described elsewhere (3); augmentation of the zone at the junction of amoxicillinclavulanate and aztreonam/ceftriaxone/ ceftazidime zones confirmed that indeed it was. In the past few years, third-generation cephalosporin resistance in S. Enteritidis has been described in Europe (4), the United States (5), Turkey (6), India (7,8), and Argentina (9). Few reports exist of extended-spectrum betalactamasemediated third-generation cephalosporin resistance in Salmonella spp. To our knowledge, this is the first report of this type of resistance among S. Enteritidis in the Caribbean. This patient was treated with ciprofloxacin for 1 week; subsequent blood cultures were negative. This unusual isolate highlights the need to establish an antimicrobial resistance surveillance network for Salmonella isolates, including S. Enteritidis, to monitor the trends and new types of resistance mechanisms in the Caribbean. An epidemiologic study of S. Enteritidis infections is being planned to describe the extent of the problem and to define risk factors and vehicles of human infections in three Caribbean countries, including Trinidad and Tobago. |
| Starting Page | 181 |
| Ending Page | 182 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 10081693v1 |
| Volume Number | 5 |
| Journal | Emerging infectious diseases |
| Alternate Webpage(s) | http://wwwnc.cdc.gov/eid/article/5/1/pdfs/99-0128.pdf |
| Alternate Webpage(s) | https://wwwnc.cdc.gov/eid/article/5/1/pdfs/99-0128.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aminoglycosides Amoxicillin / Clavulanate Ampicillin Aztreonam Blood culture Cefotaxime Ceftazidime Ceftriaxone Cephalosporin Resistance Cephalosporins Chloramphenicol Ciprofloxacin Classification Drug vehicle Epidemiology Fever Gastrointestinal tract structure Gentamicins Imipenem Infection Malnutrition Multiple Myeloma Ninety Nine Norfloxacin Ofloxacin Pathogenic organism Patients Penicillins Physical therapy Piperacillin Salmonella XXX Cult Salmonella enteritidis Ab.IgG:PrThr:Pt:Eggylk:Ord Salmonella enteritidis:PrThr:Pt:Stool:Ord:Organism specific culture Salmonella infections Seventy Nine Sulfamethoxazole Trimethoprim Trimethoprim-Sulfamethoxazole Combination beta-Lactamase piperacillin-tazobactam combination tazobactam |
| Content Type | Text |
| Resource Type | Article |
