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Assessment of the gonadotrophin-gonadal axis in androgen insensitivity syndrome.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ahmed, S. Faisal Cheng, Andrew Hua An Hughes, Ieuan A. |
| Copyright Year | 1999 |
| Abstract | OBJECTIVE To study the value of measuring serum luteinising hormone (LH), follicle stimulating hormone (FSH), testosterone, and dihydrotestosterone (DHT) in androgen insensitivity syndrome (AIS). DESIGN Retrospective study of patients on a nationwide register of AIS. PATIENTS Sixty one cases of AIS with androgen receptor (AR) dysfunction (abnormalities of the AR gene and/or abnormal AR binding) were divided into three age groups: infants, < 1 year old; children, 1-13 years old; and postpubertal, > 13 years old. MEASUREMENTS Age, dose of human chorionic gonadotrophin (hCG) stimulation, pre-hCG and post-hCG serum testosterone values, serum DHT values, and serum LH and FSH values before and after LH releasing hormone (LHRH) stimulation. RESULTS In 23 of 30 infants testosterone was within age related reference ranges; six were above this range. The median testosterone rise following variable dosage of hCG was 9.5 times the basal value. The increment was not related to the hCG dose, age, or basal concentration of testosterone. The median basal and stimulated testosterone:DHT ratios were 2.5 and 6.1, respectively. The median increment in DHT was 2.2-fold. Seventeen of 18 FSH and 11 of 19 LH measurements were within age related ranges in infants; in seven patients LH values were above the range. LHRH stimulation performed in 39 patients showed an exaggerated LH in all age groups. The FSH response was not exaggerated in children. CONCLUSION Although a positive hCG test excludes biosynthetic defects of testosterone, an inadequate response does not exclude AIS. Basal LH and testosterone may not be raised during early infancy. An LHRH stimulation test might be useful for evaluating cases of suspected AIS presenting in mid-childhood. |
| Starting Page | 1014 |
| Ending Page | 1020 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://adc.bmj.com/content/archdischild/80/4/324.full.pdf |
| PubMed reference number | 10086936v1 |
| Volume Number | 80 |
| Issue Number | 4 |
| Journal | Archives of disease in childhood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Androgen-Insensitivity Syndrome Androgens Axis vertebra Congenital Abnormality Dihydrotestosterone Erectile dysfunction Gonadal structure Gonadorelin Gonadotropins Human Chorionic Gonadotropin Luteinizing Hormone Ovarian Follicle Patients Testosterone Urofollitropin Wolff-Parkinson-White Syndrome |
| Content Type | Text |
| Resource Type | Article |
