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Orchidectomy selectively increases follicle-stimulating hormone secretion in gonadotropin-releasing hormone antagonist-treated male rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tena-Sempere, Manuel Pinilla, Leonor Aguilar, Enrique |
| Copyright Year | 1995 |
| Abstract | The pituitary component of the feedback mechanisms exerted by testicular factors on gonadotropin secretion was analyzed in adult male rats treated with a potent gonadotropin-releasing hormone (GnRH) antagonist. In order to discriminate between androgens and testicular peptides, groups of males were orchidectomized (to eliminate androgens and non-androgenic testicular factors) or injected with ethylene dimethane sulfonate (EDS), a selective toxin for Leydig cells (to eliminate selectively androgens) and treated for 15 days with vehicle or the GnRH antagonist Ac-D-pClPhe-D-pClPhe-D-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-D-Ala-+ ++NH2CH3COOH (Org.30276, 5 mg/kg/72 hours). Serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured 7 and 14 days after the beginning of treatment. We found that: in males treated with GnRH antagonist, orchidectomy or EDS treatment did not induce any increase in LH secretion; and orchidectomy, but not EDS treatment, increased FSH secretion in GnRH-treated males. The present results show that negative feedback of testicular factors on LH secretion is mediated completely through changes in GnRH actions. In contrast, a part of the inhibitory action of the testis on FSH secretion is exerted directly at the pituitary level. It can be hypothesized that non-Leydig cell testicular factor(s) inputs at different levels of the hypothalamic-pituitary axis in controlling LH and FSH secretion. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://eje.bioscientifica.com/downloadpdf/journals/eje/132/3/eje_132_3_019.pdf |
| PubMed reference number | 7889186v1 |
| Volume Number | 132 |
| Issue Number | 3 |
| Journal | European journal of endocrinology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Androgens Axis vertebra Ehlers-Danlos Syndrome Follicle Stimulating Hormone Gonadorelin Gonadotropin releasing hormone antagonist Gonadotropins Leucine Leukemia, B-Cell Orchiectomy Ovarian Follicle Stimulation (motivation) Tyrosine ethylene dimethanesulfonate gonadotropin secretion |
| Content Type | Text |
| Resource Type | Article |
