NDLI: Hypothesis testing of the aging male gonadal axis via a biomathematical construct.

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Hypothesis testing of the aging male gonadal axis via a biomathematical construct.

Content Provider	Semantic Scholar
Copyright Year	2001
Abstract	Neuroendocrine axes are feedback- and feedforward-coupled dynamic ensembles. Disruption of selected pathways in such networklike organizations may explicate loss of orderly hormonal output as observed in aging. To test this notion more explicitly, we implemented an earlier computer-assisted biomathematical model of the interlinked male hypothalamo [gonadotropin-releasing hormone (GnRH)]-pituitary [luteinizing hormone, (LH)]-testicular [Leydig cell testosterone (Te)] axis (Am J Physiol Endocrinol Metab Physiol 275: E157--E176, 1988; Keenan D., W. Sun, and J. D. Veldhuis, SIAM J Appl Math 61: 934--965, 2000). Thereby, we appraise mechanistic hypotheses for more disorderly LH and Te secretion in aging men. We compare model predictions with monitored abnormalities in the older male, namely, irregular patterns of individual and synchronous LH and Te release, reduced 24-h rhythmic Te output, and variably elevated LH secretion. Among the mechanisms examined, the most parsimonious aging hypothesis would entail impaired LH feedforward on Te without or with attenuated Te feedback on GnRH/LH secretion. This investigative strategy should aid in exploring new postulates of disrupted feedback networks in pathophysiology.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpregu.physiology.org/content/ajpregu/280/6/R1755.full.pdf
PubMed reference number	11353681v1
Volume Number	280
Issue Number	6
Journal	American journal of physiology. Regulatory, integrative and comparative physiology
Language	English
Access Restriction	Open
Subject Keyword	APPL1 gene Axis vertebra Congenital Abnormality Gonadal structure Gonadorelin Gonadotropins Leukemia, B-Cell Tellurium Testosterone
Content Type	Text
Resource Type	Article

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