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Androgen and gonadotropin patterns differ in HIV-1-infected men who develop lipoatrophy during antiretroviral therapy: a case-control study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wunder, Dorothea M. Fux, Christof A. Bersinger, Nick A. Müller, Nicole J. Hirschel, Bernard Cavassini, Matthias Elzi, Luigia Schmid, Patrick Bernasconi, Enos Müller, Barbara Thereisa Furrer, Hansjakob |
| Copyright Year | 2008 |
| Abstract | OBJECTIVES We compared androgen and gonadotropin values in HIV-infected men who did and did not develop lipoatrophy on combination antiretroviral therapy (cART). METHODS From a population of 136 treatment-naïve male Caucasians under successful zidovudine/lamivudine-based cART, the 10 patients developing lipoatrophy (cases) were compared with 87 randomly chosen controls. Plasma levels of free testosterone (fT), dehydroepiandrosterone (DHEA), follicle-stimulating hormone and luteinizing hormone (LH) were measured at baseline and after 2 years of cART. RESULTS At baseline, 60% of the cases and 71% of the controls showed abnormally low fT values. LH levels were normal or low in 67 and 94% of the patients, respectively, indicating a disturbance of the hypothalamic-pituitary-gonadal axis. fT levels did not significantly change after 2 years of cART. Cases showed a significant increase in LH levels, while controls showed a significant increase in DHEA levels. In a multivariate logistic regression model, lipoatrophy was associated with higher baseline DHEA levels (P=0.04), an increase in LH levels during cART (P=0.001), a lower body mass index and greater age. CONCLUSIONS Hypogonadism is present in the majority of HIV-infected patients. The development of cART-related lipoatrophy is associated with an increase in LH and a lack of increase in DHEA levels. |
| Starting Page | 95 |
| Ending Page | 101 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://infekt.ch/content/uploads/2013/11/Wunder_2008_BHA_GonadalAxis.pdf |
| PubMed reference number | 18459947v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1468-1293.2008.00578.x |
| DOI | 10.1111/j.1468-1293.2008.00578.x |
| Journal | HIV medicine |
| Volume Number | 9 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Androgens Antiretroviral therapy Axis vertebra BaseLine dental cement Body mass index Follicle Stimulating Hormone Free testosterone Gonadal structure Gonadorelin HIV Infections Hypogonadism Lamivudine Lipoatrophy Ovarian Follicle Patients Stimulation (motivation) Zidovudine dehydroepiandrosterone |
| Content Type | Text |
| Resource Type | Article |
