NDLI: Follicle stimulating hormone, luteinizing hormone and testicular Leydig cell responses to estradiol immunization in Ile-de-France rams.

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Follicle stimulating hormone, luteinizing hormone and testicular Leydig cell responses to estradiol immunization in Ile-de-France rams.

Content Provider	Semantic Scholar
Author	Schanbacher, Bruce D. Pelletier, J. Reviers, Marie Thérèse Hochereau-De
Copyright Year	1987
Abstract	Active immunization of Ile-de-France rams against estradiol (E2) resulted in the production of E2-neutralizing antibodies and an elevation in the plasma concentrations of FSH, LH, and testosterone. The presence of E2 antibodies did not affect the testosterone metabolic clearance rate, indicating that the immunization-mediated 10-fold increase in plasma testosterone was the result of a 10-fold increase in testicular testosterone production. Testis weights, as well as nuclear and cytoplasmic volumes of individual peritubular and perivascular Leydig cells, were greater in E2-immunized rams than in albumin-immunized controls. Leydig cell numbers were not affected by treatment. The E2 antibodies were capable not only of neutralizing the inhibitory effects of endogenous E2 on gonadotropin levels in intact rams, but were able to block the effects of exogenously administered E2 on their FSH and LH secretory response to castration. It is concluded that circulating E2 in the ram is involved in pituitary-testicular endocrine homeostasis and that E2 immunoneutralization can be employed to enhance testosterone secretion in this species.
Starting Page	97
Ending Page	102
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1300&context=hruskareports
PubMed reference number	3108223v1
Volume Number	8
Issue Number	2
Journal	Journal of andrology
Language	English
Access Restriction	Open
Subject Keyword	Castration Cell Count Cell secretion Dinoprostone Estradiol Gonadorelin Gonadotropins Isoleucine Leukemia, B-Cell Ovarian Follicle Stimulation (motivation) Testis Testosterone Secretion Process Urofollitropin Weight
Content Type	Text
Resource Type	Article

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