NDLI: Effects of active immunization against gonadotropin releasing hormone on gonadotropin secretion after ovariectomy and testosterone propionate administration to mares.

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Effects of active immunization against gonadotropin releasing hormone on gonadotropin secretion after ovariectomy and testosterone propionate administration to mares.

Content Provider	Semantic Scholar
Author	Garza, Frank Mitchell, Peter S. R. Wiest, J. J.
Copyright Year	1988
Abstract	Five lighthorse mares were actively immunized against gonadotropin releasing hormone (GnRH) conjugated to bovine serum albumin (BSA) to study the involvement of GnRH in luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion following ovariectomy (OVX) and after administration of testosterone propionate (TP). Five mares immunized against BSA served as controls. Immunizations were started on November 1, and OVX was performed in June (d 1). All mares were treated with TP from d 50 to 59 after OVX. On the day of OVX, concentrations of LH were lower (P less than .05) in GnRH-immunized mares than in BSA-immunized mares and were generally nondetectable; FSH concentrations were reduced (P less than .05) by 50% in GnRH-immunized mares relative to BSA-immunized mares. In contrast to BSA-immunized mares, plasma concentrations of LH or FSH did not increase after OVX in GnRH-immunized mares. The LH response to GnRH analog (less than .1% cross-reactive with GnRH antibodies) on d 50 was reduced (P less than .05) by 97% in GnRH-immunized mares relative to BSA-immunized mares, whereas the FSH response was similar for both groups. Treatment with TP for 10 d reduced (P less than .01) the LH response and increased (P less than .01) the FSH response to GnRH analog in BSA-immunized mares, but it had no effect (P greater than .1) on the response of either gonadotropin in GnRH-immunized mares.(ABSTRACT TRUNCATED AT 250 WORDS)
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.animalsciencepublications.org/publications/jas/pdfs/66/2/JAN0660020479
PubMed reference number	3131292v1
Volume Number	66
Issue Number	2
Journal	Journal of animal science
Language	English
Access Restriction	Open
Subject Keyword	Analog Cattle Cross Reactions Fifty Nine Gonadorelin Gonadotropins Immunization Immunostimulating conjugate (antigen) Luteinizing Hormone-releasing Hormone Agonist Ovarian Follicle Ovariectomy Propionates Serum Albumin, Bovine Stimulation (motivation) Testosterone Propionate gonadotropin secretion
Content Type	Text
Resource Type	Article

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