NDLI: Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam.

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Distribution of extended-spectrum beta-lactamases in clinical isolates of Enterobacteriaceae in Vietnam.

Content Provider	Semantic Scholar
Author	Lambert, Thierry Nhu, Duong Quynh Loan, Huynh Thi Kim Hoang, Nguyen Thi Kim Arlet, Guillaume Courvalin, Patrice
Copyright Year	2002
Abstract	Among 730 Escherichia coli, 438 Klebsiella pneumoniae, and 141 Proteus mirabilis isolates obtained between September 2000 and September 2001 in seven hospitals in Ho Chi Minh City, Vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant to cefoperazone, and 6% were resistant to cefepime. Resistance to imipenem was found in 5.6% of the isolates. In 55 strains producing extended-spectrum beta-lactamases (32 E. coli isolates, 13 K. pneumoniae isolates, and 10 P. mirabilis isolates), structural genes for VEB-1 (25.5%), CTX-M (25.5%), SHV (38.1%), and TEM (76.3%) enzymes were detected alone or in combination. Sequencing of the PCR products obtained from the K. pneumoniae isolates revealed the presence of bla(VEB-1), bla(CTX-M-14), bla(CTX-M-17), bla(SHV-2), and bla(TEM-1). Molecular typing of the strains with a similar resistance phenotype to broad-spectrum cephalosporins indicated polyclonal spread. ISEcp1 was presumably responsible for dissemination of the bla(CTX-M-like) gene.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://aac.asm.org/content/46/12/3739.full.pdf
PubMed reference number	12435670v1
Volume Number	46
Issue Number	12
Journal	Antimicrobial agents and chemotherapy
Language	English
Access Restriction	Open
Subject Keyword	Cefoperazone Cefotaxime Ceftazidime Ceftriaxone Cephalosporins Imipenem Klebsiella pneumoniae Mycological Typing Techniques Pasteurella multocida serotype:Prid:Pt:XXX:Nom:Immunoelectrophoresis Pneumonia Proteus mirabilis Rifamycins Tai Ji beta-Lactamase cefepime
Content Type	Text
Resource Type	Article

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