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Outer membrane protein profiles of clonally related Klebsiella pneumoniae isolates that differ in cefoxitin resistance.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Skopková-Zarnayová, Martina Siebor, Eliane Rovná, Daniela Bujdáková, H. Neuwirth, Catherine |
| Copyright Year | 2005 |
| Abstract | Eleven genotypically related Klebsiella pneumoniae isolates were obtained from 11 patients. All isolates were resistant to third-generation cephalosporins due to the production of SHV-2a extended-spectrum beta-lactamase. Comparison of the outer membrane protein profiles revealed one isolate that lacked porins. This porin-deficient isolate was also resistant to cefoxitin (MIC 128 microg ml(-1)) and moxalactam (MIC 64 microg ml(-1)) and had elevated MIC of meropenem (2 microg ml(-1)) when compared to porin-expressing isolates (2-8, 4 and <0.06-0.125 microg ml(-1), respectively). Higher MICs, associated with loss of porins in outer membrane, were also observed for cefotaxime (4-8-fold), cefepime (>2-16-fold), ciprofloxacin (4-16-fold), imipenem and aztreonam (2-16-fold), but there was no significant difference among MICs of ceftazidime. The porin-deficient mutant was probably selected in vivo during ofloxacin therapy. |
| Starting Page | 197 |
| Ending Page | 203 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/femsle/243/1/10.1016/j.femsle.2004.12.023/2/243-1-197.pdf?Expires=1496186466&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Hkdg3-mzRaOROx9qTCj5T4V2U2r-pbZr4XxHna9zzIYaYjo99CTXKLfsJA3F7aZTBggG5jLLYvgAQaFpw7p2EYVKJXmgjyGGawkzNdf1otPLI7tI05rg5xFWDeQXDkwqSjsGvMyJ2Lv7hhyvyIaAvYS1nXoK7xwt-GUnZL8YW5umQlyRWR8tGQyvaq5lZ2BTSatqpUQ9lYbluLSgo1yWG2m8o6ex-l~I1S6a46YAHgaw5fwN52u--O1yth4CutEjKhzcshTYX274nY5T1rTFmvb92xMDm8mb8f2WlXKKnlyK3PxhwANP3mY9SvA8ID4JQvGjdVQtb5GqANTdquCo1g__ |
| PubMed reference number | 15668019v1 |
| Volume Number | 243 |
| Issue Number | 1 |
| Journal | FEMS microbiology letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aztreonam Cefotaxime Cefoxitin Ceftazidime Cephalosporins Ciprofloxacin Imipenem Klebsiella pneumoniae Membrane Proteins Moxalactam Ofloxacin Patients Pneumonia beta-Lactamase cefepime meropenem outer membrane porin |
| Content Type | Text |
| Resource Type | Article |
