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Heat shock proteins in cancer: chaperones of tumorigenesis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Calderwood, Stuart K. Khaleque, Abdul Sawyer, Douglas Brian Ciocca, Daniel Ramón |
| Copyright Year | 2006 |
| Abstract | The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide range of tumors and are closely associated with a poor prognosis and resistance to therapy. The increased transcription of HSPs in tumor cells is due to loss of p53 function and to higher expression of the proto-oncogenes HER2 and c-Myc, and is crucial to tumorigenesis. The HSP family members play overlapping, essential roles in tumor growth both by promoting autonomous cell proliferation and by inhibiting death pathways. The HSPs have thus become targets for rational anti-cancer drug design: HSP90 inhibitors are currently showing much promise in clinical trials, whereas the increased expression of HSPs in tumors is forming the basis of chaperone-based immunotherapy. |
| Starting Page | 137 |
| Ending Page | 138 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.mdpi.com/journal/cancers/special_issue_flyer_pdf/hsp-cancer/web |
| PubMed reference number | 16483782v1 |
| Volume Number | 31 |
| Issue Number | 3 |
| Journal | Trends in biochemical sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antineoplastic Agents Carcinogenesis Cell Proliferation Cessation of life Drug Design HSP72 Heat-Shock Proteins HSP90 Heat-Shock Proteins Heat shock proteins Heat-Shock Response Molecular Chaperones Neoplasms Oncogenes Promotion (action) Proto-Oncogenes |
| Content Type | Text |
| Resource Type | Article |
