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Oncogenes and anti-oncogenes in tumorigenesis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Monier, Roger |
| Copyright Year | 1990 |
| Abstract | Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phenotype is dominant. The anti-oncogenes or tumor suppressor genes or recessive oncogenes are normally implicated in a negative regulation of cellular proliferation. The loss of their activity contributes to tumorigenesis in a recessive manner. Genetic events activating proto-oncogenes or inactivating anti-oncogenes accumulate in the same cell during tumor progression and co-operate to determine the malignant invasive phenotype of advanced tumors. |
| Starting Page | 076401 |
| Ending Page | 076401 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://rnd.edpsciences.org/articles/rnd/pdf/1990/03/RND_0181-1916_1990_30_3_ART0019.pdf |
| PubMed reference number | 2144424v1 |
| Volume Number | 30 |
| Issue Number | 3 |
| Journal | Reproduction, nutrition, development |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Carcinogenesis Cell Proliferation Genes, Suppressor Neoplasms Oncogenes Proto-Oncogenes Transcription Initiation Tumor Progression Tumor Suppressor Genes |
| Content Type | Text |
| Resource Type | Article |
