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HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Xiaoxia Chen, Meijuan Zhou, Jing Zhang, Xu |
| Copyright Year | 2014 |
| Abstract | Among the heat shock proteins (HSP), HSP27, HSP70 and HSP90 are the most studied stress-inducible HSPs, and are induced in response to a wide variety of physiological and environmental insults, thus allowing cells to survive to lethal conditions based on their powerful cytoprotective functions. Different functions of HSPs have been described to explain their cytoprotective functions, including their most basic role as molecular chaperones, that is to regulate protein folding, transport, translocation and assembly, especially helping in the refolding of misfolded proteins, as well as their anti-apoptotic properties. In cancer cells, the expression and/or activity of the three HSPs is abnormally high, and is associated with increased tumorigenicity, metastatic potential of cancer cells and resistance to chemotherapy. Associating with key apoptotic factors, they are powerful anti-apoptotic proteins, having the capacity to block the cell death process at different levels. Altogether, the properties suggest that HSP27, HSP70 and HSP90 are appropriate targets for modulating cell death pathways. In this review, we summarize the role of HSP90, HSP70 and HSP27 in apoptosis and the emerging strategies that have been developed for cancer therapy based on the inhibition of the three HSPs. |
| Starting Page | 18 |
| Ending Page | 30 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ijo/45/1/18/download |
| PubMed reference number | 24789222v1 |
| Alternate Webpage(s) | https://doi.org/10.3892/ijo.2014.2399 |
| DOI | 10.3892/ijo.2014.2399 |
| Journal | International journal of oncology |
| Volume Number | 45 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Cell Death Cessation of life HSP90 Heat-Shock Proteins Heat shock proteins Heat-Shock Response Molecular Chaperones Neoplasms Tumorigenicity cancer cell cancer therapy protein folding |
| Content Type | Text |
| Resource Type | Article |
