Loading...
Please wait, while we are loading the content...
Similar Documents
‹ler‹ Konjest‹f Kalp Yeters‹zl‹kl‹ Hastalarda Karved‹lolün Sol Ventr‹kül Fonks‹yonlari Ve Ar‹tm‹ Üzer‹ne Etk‹s‹
| Content Provider | Semantic Scholar |
|---|---|
| Author | Canbaz, Bülent Kurt, Tülin |
| Copyright Year | 2008 |
| Abstract | OZET Amac: ‹leri evre kalp yetersizlii(KY) olan hastalarda sempatik sistemde art›fla bal› aritmi ve ani olum s›kd›r. Be- ta bloker ve alfa-bloker ozellii olan karvedilol, KY tedavisinde beklentilere neden olmufltur. Cal›flmam›z›n amac› ileri evre KY olan hastalarda tedaviye eklenen karvedilolun sol ventrikul fonksiyonlar› ve aritmi geliflimine etkisi- ni araflt›rmakt›r. Gerec ve yontem: Cal›flmaya sinus ritminde ileri evre KY olan, beta bloker kullanmayan 31 hasta (ortalama yafl: 60 ± 10 y›l, K /E:11/20) al›nd›. Hastalara ekokardiyografi, 24 saatlik ritm Holteri ve kalp h›z› deiflkenlik analizi (HRV), sinyal ortalamal› EKG analizi yap›ld›ktan sonra, almakta olduklar› (diuretik ve ACEI) tedaviye ilaveten, karvedilol 2 x 3.125 baflland›. Karvedilol dozu tolere edebildikleri ust s›n›ra c›k›ld›, 12. ve 24. haftada tetkikler tek- rarland›. ABSTRACT Objective: Arrhythmia are seen frequently in patients with heart failure (HF). Carvedilol which has both beta-bloc- ker and alfa-blocker properties has led to new expectations in the treatment of HF. Our aim is to explore the effect of carvedilol on left ventricular (LV) function and development of arrhythmia in patients with HF. Materials and method: Thirty-one patients (60±10 years, F/M:11/20) were enrolled for the study who had advan- ced HF in sinus rhythm. After echocardiography, 24 hour Holter, heart rate variability analysis (HRV), signal ave- raged ECG, carvedilol was added to their treatment(diuretic and ACEI). Carvedilol dosage was increased to the up- per tolerable limit. The same analysis were repeated in 12th and 24th week. Results: Marked improvement was found in LV function in 12 and 24th week (respectively; EF %30.1 ± 6.3 vs 33.8 ± 6.8, p:0.005, Tei index: 0.50 ± 0.21 vs 0.40 ± 0.15, p:0.006 and EF % 30.1 ± 6.3 vs 33.7 ± 6.6, p:0.01, Tei |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://dergipark.org.tr/tr/download/article-file/98364 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |