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Basal vascular tone in the kidney. Evaluation from the static pressure-flow relationship under normal autoregulation and at maximal dilation in the dog.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Groß, Rainer Brandstetter, K. |
| Copyright Year | 1976 |
| Abstract | In conscious dogs static pressure-flow relationships (I-P curves) were obtained both for the normal autoregulating kidney vasculature and under conditions of maximal vasodilation induced by infusion of papaverine or acetylcholine into the renal artery. Concentration-response curves for the substances infused showed the typical S-shape. Control I-P curves exhibited an autoregulatory plateau; under maximal vasodilation the I-P curves were pressure-passive up to a perfusion pressure of 50 mm Hg, following a power function (1 = a-Pn) with an exponent greater than 1. Under the influence of acetylcholine, renal blood flow was significantly higher than under control conditions even at a perfusion pressure of 20 mm Hg. This indicates that there is an appreciable vascular tone even at a low pressure. The I-P curves under acetylcholine showed a break at about 50 mm Hg, above which the I-P curves were straight lines. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circres.ahajournals.org/content/circresaha/38/6/525.full.pdf?download=true |
| Alternate Webpage(s) | http://circres.ahajournals.org/content/circresaha/38/6/525.full.pdf |
| PubMed reference number | 1269102v1 |
| Volume Number | 38 |
| Issue Number | 6 |
| Journal | Circulation research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Blood supply aspects Canis familiaris Homeostasis Mercury Papaverine Pathological Dilatation Renal Circulation Renal Tissue Structure of renal artery |
| Content Type | Text |
| Resource Type | Article |
