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Experimental unilateral renal artery constriction in the dog.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lupu, Andrei N. Maxwell, Morton H. Kaufman, Jonathan J. White, F. Norman |
| Copyright Year | 1972 |
| Abstract | Chronic hypertension caused by unilateral constriction of the renal artery in the presence of the opposite untouched kidney can be produced in the dog by progressive plication of the renal artery over a period of several hours. Twentythree female dogs were studied. Mean arterial blood pressure was measured in the unanesthetized recumbent dog by direct puncture of the femoral artery. Reproducible control blood pressure readings were obtained only after daily training of the animals for at least 2 months. Mean arterial blood pressure for the whole group of animals was 98.25 ± 7.45 (SD) mm Hg prior to constriction. Three months after constriction, the mean arterial blood pressure of the group of dogs with a 50-63* reduction in renal blood flow was 132.4 ±5.51 (SD) mm Hg (P < 0.001); for the group with a 78-86% reduction in renal blood flow it was 144.68 ± 10.68 (SD) mm Hg ( P < 0.001). Six dogs from these two groups underwent ipsilateral nephrectomies 4—16 months after constriction, and their elevated arterial blood pressures returned to preconstriction normal values. It was concluded that this type of experimental hypertension in the dog is renal dependent in both the acute and the chronic stages. |
| Starting Page | 1803 |
| Ending Page | 1803 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circres.ahajournals.org/content/circresaha/30/5/567.full.pdf |
| Alternate Webpage(s) | http://circres.ahajournals.org/content/circresaha/30/5/567.full.pdf?download=true |
| PubMed reference number | 5026758v1 |
| Volume Number | 30 |
| Issue Number | 5 |
| Journal | Circulation research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Canis familiaris Dietary Mercury Hypertensive disease Kidney Diseases Nephrectomy Puncture procedure Renal Circulation Renal Tissue Structure of femoral artery Structure of renal artery |
| Content Type | Text |
| Resource Type | Article |
