The importance of aerobic metabolism in the renal concentrating process.

Content Provider	Semantic Scholar
Author	Weinstein, Ehud Manitius, Andrzej Epstein, Franklin H.
Copyright Year	1969
Abstract	The extent to which the concentrating function of the kidney depends on oxidative processes was investigated by infusing cyanide into one renal artery of dogs undergoing mild mannitol diuresis while receiving an infusion of vasopressin. This produced an abrupt fall in concentrating capacity (T(c) (H2O)) that was reversed when the cyanide infusion was stopped. The change could not be accounted for by the accompanying solute diuresis, since it was not reproduced by increasing the rate of mannitol infusion. The reduction in T(c) (H2O) induced by cyanide did not result from increased delivery of dilute urine to the collecting ducts, since free water clearance (C(H2O)), studied in other dogs during water diuresis, was unchanged or decreased by cyanide. Cyanide produced renal vasodilatation, as did intraarterial acetylcholine, but in contrast to the striking reduction in concentrating capacity evoked by cyanide, T(c) (H2O) was not significantly changed by acetylcholine. The data indicate that concentrating ability is closely tied to oxidative metabolism in the kidney, and it is suggested that the region where this is critically important is the red medulla and the thick ascending limb of Henle's loop.
Starting Page	1726
Ending Page	1729
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://dm5migu4zj3pb.cloudfront.net/manuscripts/106000/106151/JCI69106151.pdf
PubMed reference number	5822590v1
Volume Number	48
Issue Number	10
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Acetylcholine Blind Loop Syndrome Canis familiaris Cell Respiration Cyanides Diuresis Duct (organ) structure Kidney Diseases Mannitol Renal Tissue Sodium Cyanide Structure of renal artery Vasodilation Vasopressins Water solute
Content Type	Text
Resource Type	Article