Basal vascular tone in the kidney. Evaluation from the static pressure-flow relationship under normal autoregulation and at maximal dilation in the dog.

Content Provider	Semantic Scholar
Author	Gross, Ruth Belov Kirchheim, Hartmut R. Brandstetter, K.
Copyright Year	1976
Abstract	In conscious dogs static pressure-flow relationships (I-P curves) were obtained both for the normal autoregulating kidney vasculature and under conditions of maximal vasodilation induced by infusion of papaverine or acetylcholine into the renal artery. Concentration-response curves for the substances infused showed the typical S-shape. Control I-P curves exhibited an autoregulatory plateau; under maximal vasodilation the I-P curves were pressure-passive up to a perfusion pressure of 50 mm Hg, following a power function (1 = a-Pn) with an exponent greater than 1. Under the influence of acetylcholine, renal blood flow was significantly higher than under control conditions even at a perfusion pressure of 20 mm Hg. This indicates that there is an appreciable vascular tone even at a low pressure. The I-P curves under acetylcholine showed a break at about 50 mm Hg, above which the I-P curves were straight lines.
File Format	PDF HTM / HTML
DOI	10.1161/01.RES.38.6.525
PubMed reference number	1269102
Journal	Medline
Volume Number	38
Issue Number	6
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/38/6/525.full.pdf
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/38/6/525.full.pdf?download=true
Alternate Webpage(s)	https://doi.org/10.1161/01.RES.38.6.525
Journal	Circulation research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article