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SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yuan, Min Hall, Lucinda M. C. Savelkoul, Paul H. M. Vandenbroucke-Grauls, Christina M. J. E. Livermore, David Martin |
| Copyright Year | 2000 |
| Abstract | Eleven clonally related Klebsiella pneumoniae isolates were examined. These had been isolated at an intensive care unit in Amsterdam in 1994. Their resistance was associated with a conjugative 170-kb plasmid which encoded a novel SHV beta-lactamase designated SHV-13. The SHV-13 enzyme had two substitutions compared with SHV-1: Leu35Gln and Gly238Ala. It hydrolyzed cefotaxime much more rapidly than ceftazidime or aztreonam. |
| Starting Page | 275 |
| Ending Page | 279 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://aac.asm.org/content/44/4/1081.full.pdf |
| PubMed reference number | 10722518v1 |
| Volume Number | 44 |
| Issue Number | 4 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aztreonam Cefotaxime Ceftazidime Klebsiella pneumoniae Patients Pneumonia beta-Lactamase intensive care unit |
| Content Type | Text |
| Resource Type | Article |
